A Preliminary Analysis of Safety Management of Laboratory Hazardous Chemical Reagents

       Medical biology laboratories are important research and experimental sites for pharmaceutical research and development, talent cultivation, and technological breakthroughs. The safety management of hazardous chemical reagents in laboratories is a delicate and complex task that concerns the safety of laboratory personnel, experimental equipment, and laboratory assets. To ensure the smooth progress of scientific research in experimental projects, it is important to strictly control the safety management of hazardous chemical reagents in the laboratory, eliminate safety hazards from the source, and build a "safe laboratory". The safety management of hazardous chemical reagents is crucial in material storage, experimental use, and hazardous waste disposal.

       1. Develop a feasible hazardous chemical reagent management system
       Based on the existing laws and regulations on the management of hazardous chemical reagents, establish a set of medical biology laboratory hazardous chemical management systems that comply with national standards and are practical and feasible, clarify the management responsible personnel, safety responsibility management scope, and safety target assessment standards for hazardous chemical reagents. Create corresponding files and ledger records based on the categories and uses of hazardous chemical reagents involved in the existing laboratory.
       2. Strengthen safety education and training for personnel related to hazardous chemical reagents
       All personnel working in medical biology laboratories should receive regular safety training and education, which can be conducted once a month or once a quarter. The personnel involved should include laboratory, procurement, central supply, quality, facility, warehouse management, etc. If necessary, training should also be provided to other relevant external personnel. The training content should include policies and regulations, standard operating procedures, and emergency response plans. Upon completion of the training, an exam is required. For new employees, they must pass the exam before they can take up their positions. Management personnel involved in specialized management also need to undergo training and certification in relevant departments.
       3. Storage management of hazardous chemical reagents
       The storage of hazardous chemical reagents should be carried out in a hazardous chemical reagent warehouse, and the construction of the reagent warehouse should meet its applicability. If the medical biology laboratory is restricted by geographical location and cannot establish a hazardous chemical reagent warehouse, a dedicated area should be set up in the laboratory for the storage of explosion-proof reagent cabinets. The reagent cabinets should be equipped with double locks, and the quantity of hazardous chemicals stored in the cabinets should be maintained at an appropriate dose to avoid an increase in danger.

       4. Management of the use of hazardous chemical reagents
       For the daily use of hazardous chemical reagents in medical biology laboratories, careful operation should be carried out in accordance with standard operating procedures, forming standard operating procedures. If a new experimental project is launched, the initial experimental process should be completed under the leadership of the project leader, and corresponding standard operating procedures should be formulated. The procedures should have reliable execution and be reviewed, approved, and signed by the relevant person in charge before implementation. Effectively assess the safety risks associated with the use of various hazardous chemical reagents and develop corresponding measures and contingency plans. Establish a record of various hazardous chemical reagents, conduct diligent inspections in daily work, promptly identify and eliminate safety hazards, and reduce the risks posed by hazardous chemical reagents to laboratory personnel.
       5. Management of hazardous waste collection and storage
       Medical biology laboratories should strictly implement measures for the collection and disposal of "three wastes". When dealing with hazardous wastes, they should be classified and stored according to their types and characteristics, and mixed storage should be strictly avoided. After the hazardous waste is packaged and sealed, it should also be labeled on the outer surface, carefully indicating the product name, weight, date, personnel name, and other information. It should be handed over to a professional hazardous waste disposal company for hazardous waste treatment in the later stage. The disposal of hazardous waste also requires the establishment of a ledger and records for easy reference in the later stage.
       6. Emergency rescue
       The safety emergency rescue of medical biology laboratories can start from two aspects: facility allocation and personnel skill improvement. Personal protective equipment should be equipped in emergency facilities. Enhance the abilities of relevant personnel in firefighting and first aid skills, and if necessary, conduct annual safety emergency rescue drills.